Facial tissue (paper handkerchiefs) refers to a class of soft, absorbent, disposable paper that is suitable for use on the face. The term is commonly used to refer to the type of facial tissue, usually sold in boxes, that is designed to facilitate the expulsion of nasal mucus from the nose although it may refer to other types of facial tissues including napkins and wipes.

The first tissue handkerchiefs were introduced in the 1920s. They have been refined over the years, especially for softness and strength, but their basic design has remained constant. Today each person in Western Europe uses about 200 tissue handkerchiefs a year, with a variety of 'alternative' functions including the treatment of minor wounds, the cleaning of face and hands and the cleaning of spectacles.

The importance of the paper tissue on minimising the spread of an infection has been highlighted in light of fears over a swine flu epidemic. In the UK, for example, the Government ran a campaign called “Catch it, bin it, kill it”, which encouraged people to cover their mouth with a paper tissue when coughing or sneezing.